Vaccine Excipients
The information on this page was compiled from the CDC, FDA, HHS and the organization, Health Freedom Institute. (Download the original chart). A Midwestern Doc also lent their expertise.
For those who want to study the various inputs to this table and the CDC’s ever-changing narrative about what’s actually in these shots, keep reading. Otherwise, you can skip to the table.
The 2018 CDC Excipient List is the most comprehensive. The CDC has since made it almost impossible to find. We obtained a copy that you can download here. We mainly relied on the 2021 Pink Book, Appendix B, which is the latest official list of excipients from the CDC. More recently, Covid and RSV vaccines have been added to the childhood schedule, so we obtained the list of excipients from the FDA inserts (full documentation available here).
Making matters considerably more complicated, the Italian research institute Corvelva independently tests vaccine vials and finds contaminants that go well beyond those publicly disclosed by the manufacturers. While we have not incorporated their findings into our table, we encourage you to read their research (here).
The table below includes the data from the 2021 Pink Book Appendix B, FDA vaccine inserts for more recent vaccines, color coding to flag certain types of excipients, and additional information that is noted in the references below.
Cell line definitions
MRC-5 is a Diploid cell line made up of fibroblasts isolated from the lung tissue derived from a White, male, 14-week-old embryo.
WI-38 is a Diploid human cell line composed of fibroblasts derived from lung tissue of a 3-month-gestation female fetus.
HEK-293 is a cell line that was isolated from the kidney of a human embryo. It can be used in industrial biotechnology and toxicology research.
RA 27/3 Rubella Attenuated fetal kidney cells developed by Stanley Plotkin in 1964.
Vero cells are a continuous line of cells derived from the kidney of an African green monkey.
Continuous insect cell line (expresSF+®) is derived from Sf9 cells of the fall armyworm, Spodoptera frugiperda (related to moths, caterpillars and butterflies).
Color Key for Excipient Table
The color key was provided by Health Freedom Institute and augmented with information from the Package Insert or Johns Hopkins Vaccine Excipient page
-
Preservative
Preservatives prevent the growth of bacteria or
fungus in vaccines. -
Inactivating Agent
These chemicals are used to inactivate the toxins and viruses in the vaccine.
-
Antibiotic
These are used in production to prevent bacterial contamination during manufacturing.
-
Fertilizer Ingredient
Chemicals used in fertilizers are also found in vaccines. They are used as “stabilizers” and preservatives, and as part of a process to determine effectiveness, to change the acidity level.
-
Aborted Fetal Cells or Human parts
Cell lines are used to grow vaccines, and it’s possible DNA from the “host” line remains in the final vaccine. Albumin helps vaccines get past mucosal barriers, and can make a vaccine mixture more shelf stable. DNA can also be used to create a specific protein. Urea is used as a stabilizer.
-
Detergent
Chemicals that prevent viruses from clumping together in solution.
-
Heavy Metal
Heavy metals are used both as preservatives and to supercharge the activity of a vaccine in your body by stimulating more immune response.
-
Animal or Insect Parts
These are used as superchargers (adjuvants), stabilizers (to make the vaccine last longer on a shelf), or used to grow viruses for the vaccines.
| Vaccine | Ingredients | Fetal Cell Line | Other Cell Line | Source | Type | Adjuvant | Vegan | Total Aluminum(2) |
|---|---|---|---|---|---|---|---|---|
|
Vaccine:
Adenovirus
Barr Labs, Inc. 10/2019
|
Ingredients:
monosodium glutamate
sucrose D-mannose D-fructose dextrose human serum albumin potassium phosphate plasdone C anhydrous lactose microcrystalline cellulose polacrilin potassium magnesium stearate cellulose acetate phthalate alcohol acetone castor oil FD&C Yellow #6 aluminum lake dye fetal bovine serum |
Fetal Cell Line:
WI-38
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live not attentuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Anthrax (Biothrax)
Emergent BioDefense Operations Lansing LLC 11/2015, 7/2023**
|
Ingredients:
aluminum hydroxide
sodium chloride benzethonium chloride formaldehyde |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
BCG (Tice)
Organon Teknika Corp., LLC 02/2009, 2/2018**
|
Ingredients:
glycerin
asparagine citric acid potassium phosphate magnesium sulfate iron ammonium citrate lactose |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Cholera (Vaxchora)
Bavarian Nordic A/S 06/2016, 6/2024**
|
Ingredients:
ascorbic acid
Hy-Case SF (hydrolyzed casein [a protein derived from cow’s milk] sodium chloride sucrose dried lactose sodium bicarbonate sodium carbonate |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Covid (AstraZeneca)
2021
|
Ingredients:
human embryonic kidney (HEK) 293
GMOs L-histidine L-histidine hydrochloride monohydrate magnesium chloride hexahydrate polysorbate 80 ethanol sucrose sodium chloride disodium edetate dihydrate water |
Fetal Cell Line:
HEK 293
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Covid (Comirnaty)
BioNTech Manufacturing GmbH 08/2024
|
Ingredients:
lipids (0.43 mg ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 0.05 mg 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 0.09 mg 1,2-distearoyl-sn-glycero-3-phosphocholine, and 0.19 mg cholesterol)
tromethamine tromethamine hydrochloride sucrose |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
mRNA
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
Covid (Spikevax)
Moderna Tx, Inc 08/2024
|
Ingredients:
a total lipid content of 1.01 mg (SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG], cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC])
tromethamine tromethamine hydrochloride acetic acid sodium acetate trihydrate sucrose |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
mRNA
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
Dengue (Dengvaxia)
Sanofi Pasteur, Inc. 06/2019, 08/2023**
|
Ingredients:
sodium chloride
essential amino acids (including L-phenylalanine) non-essential amino acids L-arginine hydrochloride sucrose D-trehalose dihydrate D-sorbitol trometamol urea |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
DT
Sanofi Pasteur, Inc. 06/2018
|
Ingredients:
aluminum phosphate
isotonic sodium chloride formaldehyde |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
Unknown
|
|
Vaccine:
DTaP (Daptacel)
Sanofi Pasteur, Ltd. 01/2021(b), 7/2022**
|
Ingredients:
aluminum phosphate (330mcg)
formaldehyde glutaraldehyde 2-phenoxyethanol |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
(5 doses) 1,650mcg
|
|
Vaccine:
DTaP (Infanrix)
GlaxoSmithKline Biologicals 01/2021(b), 10/2023**
|
Ingredients:
formaldehyde
aluminum hydroxide (625mcg) sodium chloride polysorbate 80 (Tween 80) bovine casein and bovine extract |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(5 doses) 3,125mcg
|
|
Vaccine:
DTaP-IPV (Kinrix)
GlaxoSmithKline Biologicals 01/2021(b), 10/2023**
|
Ingredients:
formaldehyde
aluminum hydroxide (600mcg) sodium chloride polysorbate 80 (Tween 80) neomycin sulfate polymyxin B Calf serum and lactalbumin hydrolysate* |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(single booster dose) 600mcg
|
|
Vaccine:
DTaP-IPV (Quadracel)
Sanofi Pasteur Ltd. 02/2021, 07/2022**
|
Ingredients:
formaldehyde
aluminum phosphate (330mcg) 2-phenoxyethanol polysorbate 80 glutaraldehyde neomycin polymyxin B sulfate bovine serum albumin |
Fetal Cell Line:
MRC-5
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(single booster dose) 330mcg
| |
|
Vaccine:
DTaP-HepB-IPV (Pediarix)
GlaxoSmithKline 01/2021(b), 4/2023**
|
Ingredients:
formaldehyde
aluminum hydroxide and aluminum phosphate (comb. 850mcg) sodium chloride polysorbate 80 (Tween 80) neomycin sulfate polymyxin B yeast protein bovine casein* Calf serum and lactalbumin hydrolysate* |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(3 doses) 2,250mcg
|
|
Vaccine:
DTaP-IPV/Hib (Pentacel)
Sanofi Pasteur Ltd. 12/2019, 10/2022**
|
Ingredients:
aluminum phosphate (330mcg)
polysorbate 80 sucrose formaldehyde glutaraldehyde bovine serum albumin 2-phenoxyethanol neomycin polymyxin B sulfate |
Fetal Cell Line:
MRC-5
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(4 doses) 1,320mcg
| |
|
Vaccine:
DTaP-IPV-Hib-HepB (Vaxelis)
MSP Vaccine Company 10/2020, 4/2023**
|
Ingredients:
polysorbate 80
formaldehyde glutaraldehyde bovine serum albumin neomycin streptomycin sulfate polymyxin B sulfate ammonium thiocyanate yeast protein aluminum (319mcg) Amorphous Aluminum Hydroxyphosphate Sulfate (AAHS)(Unk.) |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum/AAHS
|
Vegan:
no
|
Total Aluminum(2):
915mcg + Unknown AAHS
|
|
Vaccine:
Ebola Zaire (ERVEBO)
Merck Sharp & Dohme LLC 01/2021(b), 08/2023**
|
Ingredients:
Tromethamine
rice-derived recombinant human serum albumin host cell DNA benzonase rice protein |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Hib (ActHIB)
Sanofi Pasteur Inc. 05/2019, 10/2022**
|
Ingredients:
sodium chloride
formaldehyde sucrose bovine casein derivatives |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Hib (Hiberix)
GlaxoSmithKline Biologicals 04/2018, 12/2023**
|
Ingredients:
formaldehyde
sodium chloride lactose |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Hib (PedvaxHIB)
Merck Sharp & Dohme Corp. 01/2021(b), 4/2019
|
Ingredients:
amorphous aluminum hydroxyphosphate sulfate (225mcg)
sodium chloride |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum/AAHS
|
Vegan:
-
|
Total Aluminum(2):
(2 doses) 450mcg or 625mcg* (3 doses with booster)
|
|
Vaccine:
Hep A (Havrix)
GlaxoSmithKline Biologicals 01/2021(b), 10/2023
|
Ingredients:
MRC-5 cellular proteins(4)
formalin aluminum hydroxide (adult 500mcg, child 250mcg), amino acid supplement phosphate-buffered saline solution polysorbate 20 neomycin sulfate aminoglycoside antibiotic |
Fetal Cell Line:
MRC-5
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated whole virus
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(2 doses) Adults 1000mcg/Children 500mcg
|
|
Vaccine:
Hep A (Vaqta)
Merck Sharp & Dohme Corp. 01/2021(b), 10/2020**
|
Ingredients:
amorphous aluminum hydroxyphosphate sulfate (adult 450mcg, child 225mcg)
non-viral protein DNA(4) bovine albumin formaldehyde neomycin sodium borate sodium chloride other process chemical residuals |
Fetal Cell Line:
MRC-5
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated whole virus
|
Adjuvant:
Aluminum/AAHS
|
Vegan:
no
|
Total Aluminum(2):
(2 doses) Adults 900mcg/Children 450mcg
|
|
Vaccine:
Hep B (Engerix-B)
GlaxoSmithKline Biologicals 01/2021(b), 10/2023**
|
Ingredients:
aluminum hydroxide (adult 500mcg, child 250mcg)
yeast protein sodium chloride disodium phosphate dihydrate sodium dihydrogen phosphate dihydrate |
Fetal Cell Line:
-
|
Other Cell Line:
Genetically Engineered Yeast
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
(3 doses) Adults1,500mcg/Children 750mcg
|
|
Vaccine:
Hep B (Recombivax)
Merck & Co, Inc 12/2018, 4/2019**
|
Ingredients:
formaldehyde
potassium aluminum sulfate amorphous aluminum hydroxyphosphate sulfate (adult 500mcg, child 250mcg) yeast protein |
Fetal Cell Line:
-
|
Other Cell Line:
Genetically Engineered Yeast
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum/AAHS
|
Vegan:
-
|
Total Aluminum(2):
(3 doses) Adults 1500mcg/Children 750mcg
|
|
Vaccine:
Hep B (Heplisav-B)
Dynavax Technologies Corporation 05/2020, 5/2023**
|
Ingredients:
yeast protein
yeast DNA deoxycholate phosphorothioate linked oligodeoxynucleotide sodium phosphate dibasic dodecahydrate sodium chloride monobasic dehydrate polysorbate 80 |
Fetal Cell Line:
-
|
Other Cell Line:
Genetically Engineered Yeast
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
CpG 1018
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
Hep A/Hep B (Twinrix)
GlaxoSmithKline Biologicals 01/2021(b), 4/2023**
|
Ingredients:
MRC-5 cellular proteins(4)
formalin aluminum phosphate and aluminum hydroxide (450mcg) amino acids sodium chloride phosphate buffer polysorbate 20 neomycin sulfate yeast protein |
Fetal Cell Line:
MRC-5
|
Other Cell Line:
Genetically Engineered Yeast
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
no
|
Total Aluminum(2):
(3 doses) 1,350mcg or 1,800mcg*(4 doses with booster)
|
|
Vaccine:
HPV (Gardasil 9)
Merck Sharp & Dohme LLC 08/2020, 3/2024**
|
Ingredients:
amorphous aluminum hydroxyphosphate sulfate (500mcg)
sodium chloride L-histidine polysorbate 80 sodium borate yeast protein |
Fetal Cell Line:
-
|
Other Cell Line:
Genetically Engineered Yeast
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum/AAHS
|
Vegan:
-
|
Total Aluminum(2):
(2 or 3 doses) 1,000mcg or 1,500mcg
|
|
Vaccine:
Influenza (Afluria) Quadrivalent(c)
Seqirus Pty Ltd. 03/2021, 2/2024**
|
Ingredients:
sodium chloride
monobasic sodium phosphate dibasic sodium phosphate monobasic potassium phosphate potassium chloride calcium chloride sodium taurodeoxycholate ovalbumin sucrose neomycin sulfate polymyxin B beta- propiolactone hydrocortison thimerosal (multi-dose vials)(12.5/24.5 mcg) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated
|
Vegan:
no
|
Total Aluminum(2):
-
| |
|
Vaccine:
Influenza (Fluad) Quadrivalent(c)
Seqirus, Inc. 03/2021, 7/2023**
|
Ingredients:
squalene
polysorbate 80 sorbitan trioleate sodium citrate dihydrate citric acid monohydrate neomycin kanamycin hydrocortisone egg protein formaldehyde MF59C.1 adjuvant (9.75 mg squalene, 1.175 mg of polysorbate 80, 1.175 mg of sorbitan trioleate, 0.66 mg of sodium citrate dihydrate and 0.04 mg of citric acid monohydrate) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated
|
Adjuvant:
MF59C.1 adjuvant (Squalene)
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Influenza (Fluarix) Quadrivalent(c)
GlaxoSmithKline Biologicals 2021, 7/2024**
|
Ingredients:
octoxynol-10 (TRITON X-100)
α-tocopheryl hydrogen succinate polysorbate 80 (Tween 80) hydrocortisone gentamicin sulfate ovalbumin formaldehyde sodium deoxycholate sodium phosphate-buffered isotonic sodium chloride |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Influenza (Flublok) Quadrivalent(c)
Protein Sciences Corporation 03/2021, 7/2023**
|
Ingredients:
sodium chloride
monobasic sodium phosphate dibasic sodium phosphate polysorbate 20 (Tween 20) baculovirus and Spodoptera frugiperda cell proteins baculovirus and cellular DNA Triton X-100 |
Fetal Cell Line:
-
|
Other Cell Line:
Continuous insect cell line (expresSF+®)
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Influenza (Flucelvax) Quadrivalent(c)
Seqirus, Inc. 10/2021(b), 7/2023**
|
Ingredients:
Madin Darby Canine Kidney (MDCK) cell protein
phosphate buffered saline protein other than HA MDCK cell DNA polysorbate 80 cetyltrimethlyammonium bromide β-propiolactone thimerosal (multi-dose vials) |
Fetal Cell Line:
-
|
Other Cell Line:
Madin-Darby canine kidney (MDCK) cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Influenza (Flulaval) Quadrivalent(c)
ID Biomedical Corporation of Quebec 2021, 7/2023**
|
Ingredients:
ovalbumin
formaldehyde sodium deoxycholate α-tocopheryl hydrogen succinate polysorbate 80 phosphate-buffered saline solution |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Influenza (Fluzone) Quadrivalent(c)
Sanofi Pasteur Inc. 2021, 5/2024**
|
Ingredients:
formaldehyde
egg protein octylphenol ethoxylate (Triton X-100) sodium phosphate-buffered isotonic sodium chloride solution thimerosal (multi-dose vials)(12.5mcg/25mcg) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated
|
Vegan:
no
|
Total Aluminum(2):
-
| |
|
Vaccine:
Influenza (Fluzone) High Dose(c)
Sanofi Pasteur Inc. 07/2021, 5/2024**
|
Ingredients:
egg protein
octylphenol ethoxylate (Triton X-100) sodium phosphate-buffered isotonic sodium chloride solution formaldehyde |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Influenza (FluMist) Quadrivalent(c)
MedImmune, LLC 08/2021, 7/2023**
|
Ingredients:
monosodium glutamate
hydrolyzed porcine gelatin arginine sucrose dibasic potassium phosphate monobasic potassium phosphate ovalbumin gentamicin sulfate ethylenediaminetetraacetic acid (EDTA) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
IPV (Ipol)
Sanofi Pasteur, SA 01/2021(b), 6/2022*
|
Ingredients:
calf bovine serum albumin
2-phenoxyethanol formaldehyde neomycin streptomycin polymyxin B M-199 medium |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
inactivated whole virus
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Japanese Encephalitis (Ixiaro)
Valneva Austria GmbH 09/2018, 11/2019
|
Ingredients:
aluminum hydroxide
protamine sulfate formaldehyde bovine serum albumin host cell DNA sodium metabisulphite host cell protein |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
inactivated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
MenACWY (Menactra)
Sanofi Pasteur Inc 04/2018, 11/2019**
|
Ingredients:
sodium phosphate buffered isotonic sodium chloride solution
formaldehyde diphtheria toxoid protein carrier |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
MenACWY (MenQuadfi)
Sanofi Pasteur, Inc. 01/2021(b), 6/2023**
|
Ingredients:
sodium chloride
sodium acetate formaldehyde |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
MenACWY (Menveo)
GlaxoSmithKline Biologicals SA 07/2020, 10/2022**
|
Ingredients:
formaldehyde
|
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
MenB (Bexsero)
GlaxoSmithKline Biologicals SA 01/2021(b), 8/24**
|
Ingredients:
aluminum hydroxide (no amount given)
sodium chloride histidine sucrose kanamycin |
Fetal Cell Line:
-
|
Other Cell Line:
Escherichia coli
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
unk.
|
|
Vaccine:
MenB (Trumenba)
Wyeth Pharmaceuticals, LLC, a subsidiary of Pfizer Inc. 2018, 6/2024**
|
Ingredients:
polysorbate 80
aluminum phosphate (Al3+ as AlPO4, 250mcg) histidine buffered saline |
Fetal Cell Line:
-
|
Other Cell Line:
Escherichia coli
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
(2/3 doses) 500/750mcg
|
|
Vaccine:
MMR (MMR-II)
Merck Sharp & Dohme LLC 12/2020, 8/2023**
|
Ingredients:
sorbitol
sucrose hydrolyzed gelatin recombinant human albumin neomycin fetal bovine serum WI-38 human diploid lung fibroblasts used in manufacture. |
Fetal Cell Line:
RA 27/3, WI-38
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
MMRV (ProQuad) (Frozen: Recombinant Albumin)
Merck Sharp & Dohme LLC 01/2021(b), 8/2023**
|
Ingredients:
MRC-5 cells including DNA and protein(4)
sucrose hydrolyzed gelatin sodium chloride sorbitol monosodium L-glutamate sodium phosphate dibasic recombinant human albumin sodium bicarbonate potassium phosphate monobasic potassium chloride potassium phosphate dibasic neomycin bovine calf serum other buffer and media ingredients |
Fetal Cell Line:
RA 27/3, WI-38, MRC-5
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
PCV13 (Prevnar 13)
Wyeth Pharmaceuticals, Inc. 08/2017, 12/2019
|
Ingredients:
polysorbate 80 succinate buffer aluminum phosphate (125mcg) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
4 doses in children <=5 (600mcg) 6+ yrs (125mcg)
|
|
Vaccine:
PCV20 (Prevnar 20)
Wyeth Pharmaceuticals, Inc. 06/2023
|
Ingredients:
polysorbate 80 succinate buffer aluminum phosphate (125mcg) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
4 doses in children <=15mos. (600mcg) Adults (125mcg)
|
|
Vaccine:
PPSV-23 (Pneumovax)
Merck Sharp & Dohme Corp. 09/2020, 10/2021
|
Ingredients:
isotonic saline solution
phenol |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
Rabies (Imovax)
Sanofi Pasteur 10/2019, 4/2024**
|
Ingredients:
human albumin
neomycin sulfate phenol red beta-propiolactone |
Fetal Cell Line:
MRC-5
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated whole virus
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Rabies (RabAvert)
Bavarian Nordic A/S 2018, 5/2024**
|
Ingredients:
chicken protein
polygeline (processed bovine gelatin) human serum albumin potassium glutamate sodium EDTA ovalbumin neomycin chlortetracycline amphotericin B βpropiolactone* |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
inactivated whole virus
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Rotavirus (RotaTeq)
Merck Sharp & Dohme Corp 01/2021(b)
|
Ingredients:
sucrose
sodium citrate sodium phosphate monobasic monohydrate sodium hydroxide polysorbate 80 cell culture media fetal bovine serum |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
live attenuated, oral
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Rotavirus (Rotarix)
GlaxoSmithKline Biologicals 01/2021(b), 11/2022**
|
Ingredients:
dextran
Dulbecco’s Modified Eagle Medium (sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids, L-glutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red) sorbitol sucrose calcium carbonate sterile water xanthan [Porcine circovirus type 1 (PCV1) is present in Rotarix. PCV-1 is not known to cause disease in humans.] |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
live attenuated, oral
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Respiratory Syncytial Virus Vaccine (Abrysvo)
Pfizer Inc. 07/2024**
|
Ingredients:
tromethamine
tromethamine hydrochloride sucrose mannitol polysorbate 80 sodium chloride host cell proteins and DNA |
Fetal Cell Line:
-
|
Other Cell Line:
CHO-Chinese Hamster Ovary cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Respiratory Syncytial Virus Vaccine (Arexvy)
GlaxoSmithKline Biologicals SA 08/2024**
|
Ingredients:
trehalose
sodium chloride potassium dihydrogen phosphate dipotassium phosphate polysorbate 80 disodium phosphate anhydrous dioleoyl phosphatidylcholine (DOPC) cholesterol Monophosphoryl Lipid A (MPL a chemically detoxified form of the lipopolysaccharide derived from the Gram-negative bacterium Salmonella minnesota) and QS-21 [a saponin (triterpene glycoside) purified from the bark of the South American tree Quillaja saponaria Molina] |
Fetal Cell Line:
-
|
Other Cell Line:
CHO-Chinese Hamster Ovary cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
AS01E
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
Smallpox
(Vaccinia) (ACAM2000)
Emergent Product Development Gaithersburg, Inc. 03/2018, 12/2019**
|
Ingredients:
HEPES
human serum albumin sodium chloride USP Mannitol USP neomycin polymyxin B Glycerin USP phenol USP |
Fetal Cell Line:
-
|
Other Cell Line:
Vero cells
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Smallpox/Monkeypox (Jynneos)
Bavarian Nordic 05/2024**
|
Ingredients:
Chicken Embryo Fibroblast (CEF) cells
Tris (tromethamine) sodium chloride host-cell DNA protein benzonase gentamicin ciprofloxacin |
Fetal Cell Line:
-
|
Other Cell Line:
Chicken Embryo Fibroblast (CEF) cells
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Td (Tenivac)
Sanofi Pasteur Limited 11/2019, 12/2022**
|
Ingredients:
aluminum phosphate (330mcg)
formaldehyde sodium chloride |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
(3 doses) 990mcg + boosters
|
|
Vaccine:
Td (TDVAX)
MassBiologics 09/2018
|
Ingredients:
aluminum phosphate (<=530mcg)
formaldehyde thimerosal |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
(3 doses) 1590mcg + boosters
|
|
Vaccine:
Tdap (Adacel)
Sanofi Pasteur Limited 12/2020, 5/2023**
|
Ingredients:
aluminum phosphate (330mcg)
formaldehyde 2-phenoxyethanol glutaraldehyde |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
330mcg as a booster dose as needed.
|
|
Vaccine:
Tdap (Boostrix)
GlaxoSmithKline Biologicals 09/2020, 10/2023**
|
Ingredients:
formaldehyde
aluminum hydroxide (300mcg) sodium chloride polysorbate 80(Tween 80) |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
Aluminum
|
Vegan:
-
|
Total Aluminum(2):
300mcg as a booster dose as needed.
|
|
Vaccine:
Typhoid (Typhim Vi)
Sanofi Pasteur SA 03/2020
|
Ingredients:
formaldehyde
phenol polydimethylsiloxane(silicone polymer) disodium phosphate monosodium phosphate sodium chloride |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
-
|
Vegan:
-
|
Total Aluminum(2):
-
|
|
Vaccine:
Typhoid (Vivotif Ty21a)
Berna Biotech, Ltd. 9/2013, 3/2018**
|
Ingredients:
sucrose
ascorbic acid amino acids lactose magnesium stearate gelatin |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated, oral
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Varicella (Varivax) Frozen
Merck Sharp & Dohme LLC 01/2021(b), 8/2023**
|
Ingredients:
sucrose
hydrolyzed gelatin sodium chloride monosodium L-glutamate sodium phosphate dibasic potassium phosphate monobasic potassium chloride MRC-5 human diploid cells including DNA & protein(4) sodium phosphate monobasic EDTA neomycin fetal bovine serum |
Fetal Cell Line:
WI-38, MRC-5
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Yellow Fever (YF-Vax)
Sanofi Pasteur, Inc 2/2019, 12/2019**
|
Ingredients:
sorbitol
gelatin sodium chloride egg** |
Fetal Cell Line:
-
|
Other Cell Line:
-
|
Source:
FDA Package Insert |
Type:
live attenuated
|
Adjuvant:
-
|
Vegan:
no
|
Total Aluminum(2):
-
|
|
Vaccine:
Zoster (Shingles) (Shingrix)
GlaxoSmithKline Biologicals 01/2021(b), 5/2023**
|
Ingredients:
sucrose
sodium chloride dioleoyl phosphatidylcholine (DOPC)(liposomes) 3-O-desacl- 4’monophosphoryl lipid A (MPL) QS-21 (a saponin purified from plant extract Quillaja saponaria Molina) potassium dihydrogen phosphate cholesterol sodium dihydrogen phosphate dihydrate disodium phosphate anhydrous dipotassium phosphate polysorbate 80 host cell protein and DNA |
Fetal Cell Line:
-
|
Other Cell Line:
CHO-Chinese Hamster Ovary cells
|
Source:
FDA Package Insert |
Type:
subunit, recombinant, polysaccharide, and conjugate
|
Adjuvant:
AS01B (3)
|
Vegan:
no
|
Total Aluminum(2):
-
|
Notes
(a)-(from the Pink Book) All information was extracted from manufacturers’ package inserts. The date shown in the Date column of the table is the edition date of the PI in use in January 2021 by month and year. In some cases, only a year was printed on the PI. If in doubt about whether a PI has been updated since this table was prepared, check the FDA’s website at: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htm
(b)-(from the Pink Book) The PI was not dated and this is the date the PI was reviewed for this table.
(c)-(from the Pink Book) All infuenza vaccine in this table are 2021-22 northern hemisphere formulation.
1. The CDC, in the Pink Book Appendix does publish the full list of vaccine ingredients, but it can be difficult to decipher and is sometimes incomplete or not up-to-date. The CDC says on its Excipient List, page 1, “substance used in the manufacturing of a vaccine, but not listed as contained in the final product, can be found on the package insert.” We have used both the Excipient List and Package Insert to compile this chart.
2. The last column reflects the total amount of aluminum a child or adult would get with the recommended dosing series. A typical childhood required schedule with vaccines that contain aluminum (Engerix, Infanrix, Prevnar, Vaqta and Gardasil) would be something like 6,425mcg. With Twinrix replacing the HepA/HepB it comes to 7,025mcg. This does not include a yearly flu shot, some contain aluminum, some dont.
3. “The AS01E adjuvant component is GSK’s proprietary adjuvant suspension component that contains Monophosphoryl Lipid A (b) (4) (MPL, a chemically detoxified form of the lipopolysaccharide derived from the Gram-negative bacterium Salmonella minnesota (b) (4) ) and QS-21 [a saponin (triterpene glycoside) purified from the bark of the South American tree Quillaja saponaria Molina]. To form AS01E adjuvant, MPL and QS-21 are combined in a liposomal formulation that contains the same ingredients as in AS01B adjuvant, the adjuvant in SHINGRIX, and consists of dioleoyl phosphatidylcholine (DOPC) and cholesterol in phosphate- buffered saline solution. However, AS01E adjuvant contains half the amount of MPL and QS-21 in AS01B adjuvant.”
4. The remnant DNA/Fetal proteins are listed in the Package Insert for this product. Further exploration of this topic can be found below in Sources.
Sources
- US Dept. of Health and Human Services - Vaccine Types
https://www.hhs.gov/immunization/basics/types/index.html - CDC Immunization Schedule
https://www.cdc.gov/vaccines/imz-schedules/adolescent-easyread.html - US Food & Drug Administration- Vaccines Licensed for Use in the United States
https://www.fda.gov/vaccines-blood-biologics/vaccines/vaccines-licensed-use-united-states - CDC Pink Book, Appendix B - Vaccine Excipient Summary(11-2021)
https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf - Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health - Excipients in Routinely Recommended Vaccines
https://www.vaccinesafety.edu/components-excipients/ - – – Resources on residual DNA
- Corvelva Italia, https://www.corveIva.it/speciale-corvelva/vaccinegate-en/5-of-7-vaccines-analyzed-are-not-compliant.html
https://www.corvelva.it/speciale-corvelva/vaccinegate-en/priorix-tetra-human-genome-and-mrc-5-cell-line-comparative-study.html - Vaccinegate: MRC-5 contained in Priorix Tetra - Complete genome sequencing
https://childrenshealthdefense.org/wp-content/uploads/CORVELVA-MRC-5-contained-in-Priorix-Tetra-Complete-genome-sequencing.pdf - Vaccinegate: Metagenomic analysis report on Gardasil 9
https://www.scribd.com/document/417225972/CORVELVA-Metagenomic-Analysis-Report-on-Gardasil-9 - Keith Peden Division of Viral Products Office of Vaccines Research and Review CBER, FDA, Issues Associated With Residual Cell-Substrate DNA, Vaccines and Related Biological Products Advisory Committee, November 16, 2005
http://www.cogforlife.org/FDApowerpointDNA.pdf - Yang H, Establishing acceptable limits of residual DNA, PDA J Pharm Sci Technol. 2013 Mar-Apr;67(2):155-63
https://www.ncbi.nlm.nih.gov/pubmed/23569076